2021

JOURNAL PUBLICATIONS

- Dynamical Analysis of Early Afterdepolarization Patterns in a Biophysically-detailed Cardiac Model. R. Barrio, M.A. Martínez, E. Pueyo, S. Serrano. Chaos, In press, 2021.

- Chronological and biological aging of the human left ventricular myocardium: analysis of microRNAs contribution. E. Ramos, L García, S. Srinivasan, …, G. Muñiz, J.M. Vallejo, C. Fresneda, J. Fañanás, M. Vázquez, M. Matamala, J.F. Sorribas, C. Ballester, A. Olivan, M. Segovia, E. Diez, L. Ordovás, E. Pueyo. Aging Cell, vol. 00:e13383, pp. 1-16, 2021.

- Melatonin to rescue the aged heart: antiarrhythmic and antioxidant benefits. M. Segovia-Roldan, E.R. Diez, E. Pueyo. Oxid Med Cell Longev, pp. 8876792, 2021.

- Validity of the Polar H7 heart rate sensor for heart rate variability analysis during exercise in different age, body composition and fitness level groups . A. Hernández-Vicente, D. Hernando, J. Marín-Puyalto, G. Vicente-Rodríguez, N.Garatachea, E. Pueyo, R. Bailón. Sens, vol. 21, pp. 902, 2021.

- Location of Parasympathetic Innervation Regions from Electrograms to Guide Atrial Fibrillation Ablation Therapy: An In Silico Modeling Study. C. Celotto, C. Sanchez, K. A. Mountris, P. Laguna, E. Pueyo . Front Physiol, In press, 2021.

- ECG-based monitoring of blood potassium concentration: periodic versus principal componentas lead transformation for biomarker robustness. F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna . Biomed Signal Proces, In press, 2021.

- QT variability unrelated to RR during stress testing for identification of coronary artery disease . M. González del Castillo, D. Hernando, M. Orini, P. Laguna, J. Viik, R. Bailón, E. Pueyo. Philos Trans A Math PhysEngSci, In press, 2021.

- Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia. P. Taggart, E. Pueyo, S.V. Duijvenboden, B. Porter, M. Bishop, D.A. Sampedro-Puente, M. Orini, B. Hanson, C.A. Rinaldi, J.S. Gill, P. Lambiase. Europace, pp. euab009, 2021.

- A dual adaptive explicit time integration algorithm for efficiently solving the cardiac monodomain equation. K.A. Mountris, E. Pueyo. Int J Numer Method Biomed Eng, pp. e3461, 2021.

- Nonlinear T-Wave Time Warping-Based Sensing Model for Non-Invasive Personalised Blood Potassium Monitoring in Hemodialysis Patients: A Pilot Study. F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna. Sens, vol. 21 (8), pp. 2710, 2021.

- Cardiac computational modelling . J.R. Bragard, O. Camara, B. Echebarria, L. Gerardo-Giorda, E. Pueyo, J. Saiz, R. Sebastián, E. Soudah, M. Vázquez. Rev Esp Cardiol, vol. 74, pp. 65 – 71, 2021.

- Characterization of T wave amplitude, duration and morphology changes during hemodialysis: relationship with serum electrolyte levels and heart rate. H.A. Bukhari, F. Palmieri, J. Ramírez, P. Laguna, J.E. Ruiz, D. Ferreira, M. Potse, C. Sánchez, E. Pueyo. IEEE Trans Biomed Eng, doi: 10.1109/TBME.2020.3043844, 2021.

- Characterization of spatio-temporal cardiac action potential variability at baseline and under beta-adrenergic stimulation by combined Unscented Kalman Filter and Double Greedy Dimension Reduction. D. A. Sampedro-Puente, F. Raphel, J. Fernandez-Bes, P. Laguna, D. Lombardi, E. Pueyo. IEEE J Biomed Health, vol. 25, pp. 276 – 288, 2021.

- Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics . F. Palmieri, P. Gomis, D. Ferreira, J.E. Ruiz, B. Bergasa, A. Martín-Yebra, H.A. Bukhari, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna. Sci Rep, vol. 11, pp. 3883, 2021.

2020

JOURNAL PUBLICATIONS

- Heart rate variability and exceptional longevity. A. Hernández-Vicente, D. Hernando, A. Santos-Lozano, G. Rodríguez-Romo, G. Vicente-Rodríguez, E. Pueyo, R. Bailón, N. Garatachea. Front Physiol, vol. 11, pp. 566399, 2020.

- Atrial dyssynchrony measured by strain echocardiography as a marker of proarrhythmic remodeling and oxidative stress in cardiac surgery patients. F.J. Sánchez, V.A. González, M. Farrando, A.O. Baigorria Jayat, M. Segovia-Roldán, L. García-Mendívil, L. Ordovás, N.J. Prado, E. Pueyo, E.R. Diez. Oxid Med Cell Longev, pp. 8895078, 2020.

- Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images. A. Oliver, L. García, J.M. Vallejo, P. Fresneda, K. Andelova, J. Fañanás, M. Vázquez, M. Matamala, F. Sorribas, C. Ballester, N. Tribulova, L. Ordovás, E.R. Diez, E. Pueyo. Biomolecules, vol. 10, pp. 1334, 2020.

- Bifurcations and slow-fast analysis in a cardiac cell model for investigation of early afterdepolarizations. R. Barrio, M. A. Martínez, L. Pérez, E. Pueyo. Mathematics, vol. 8, pp. 880, 2020.

- Cell-based maximum entropy approximants for three-dimensional domains: application in large strain elastodynamics using the meshless total Lagrangian explicit dynamics method. K. A. Mountris, G. C. Bourantas, D. Millán, G. R. Joldes, K. Miller, E. Pueyo, A. Wittek. Int J Numer Methods Eng, vol. 0, pp. 1 – 19, 2020.

- Complex interaction between low-frequency APD oscillations and beat-to-beat APD variability in humans is governed by the sympathetic nervous system. S. van Duijvenboden, B. Porter, E. Pueyo, D. A. Sampedro-Puente, J. Fernandez-Bes, B. Sidhu, J. Gould, M. Orini, M. Bishop, B. Hanson, P. Lambiase, R. Razavi, C. A. Rinaldi, J. S. Gill, P. Taggart. Front Physiol, vol. 10, pp. 1582, 2020.

- Data-driven Identification of Stochastic Model Parameters and State Variables: Application to the Study of Cardiac Beat-to-beat Variability. David A. Sampedro, Jesús Fernández-Bes, László Virág, András Varró, Esther Pueyo. IEEE J Biomed Health Inform, vol. 24, pp. 693 – 704, 2020.

- Estimation of the second ventilatory threshold through ventricular repolarization profile analysis. J. Milagro, A. Hernández-Vicente, D. Hernando, J.A. Casajús, N. Garatachea, R. Bailón, E. Pueyo. Scand J Med Sci Sports, vol. 31, pp. 339 – 349, 2020.

- Excitable dynamics in neural and cardiac systems. R. Barrio, S. Coombes, M. Desroches, F. Fenton, S. Luther, E. Pueyo. . Commun Nonlinear Sci Numer Simul, vol. 86, pp. 105275, 2020.

- Minimally invasive system to reliably characterize ventricular electrophysiology from living donors. A. Olivan-Viguera, M. Pérez-Zabalza, L. García-Mendívil, K.A. Mountris, S. Orós-Rodrigo, E. Ramos-Marquès, J.M. Vallejo-Gil, C. Pastor, C. Ballester-Cuenca, L. Ordovás, R. Köhler, E.R. Diez, E. Pueyo. Sci Rep , vol. 10, pp. 19941, 2020.

- Perspectives of antiarrhythmic drug therapy: disappointing past, current efforts, and faint hopes. P. Nánási, E. Pueyo, L. Virág . Front Pharmacol, vol. 11, pp. 1116, 2020.

- Reperfusion arrhythmias increase after superior cervical ganglionectomy due to conduction disorders and changes in repolarisation. N. J. Prado, E. Muñoz, L. E. Farias-Altamirano, F. Aguiar, A. Z. Ponce-Zumino, F. J. Sánchez, R. M. Miatello, E. Pueyo, E. R. Diez. Int J Mol Sci, vol. 21, pp. 1804, 2020.

- The ‘Digital Twin’ to enable the vision of precision cardiology. J. Corral-Acero, F. Margara, M. Marciniak, C. Rodero, H.A. Bukhari, V. Grau; B. Rodríguez, E. W. Remme, S. Niederer, P. Mortier, K. McLeod, M. Potse, E. Pueyo, A. Bueno-Orovio, P. Lamata. Eur Heart J, vol. 4, pp. ehaa159, 2020.

- The radial point interpolation mixed collocation method for the solution of transient diffusion problems. K. Mountris, E. Pueyo . Eng Anal Bound Elem, vol. 121, pp. 207 – 216, 2020.

- Time course of low-frequency oscillatory behavior in human ventricular repolarization following enhanced sympathetic activity and relation to arrhythmogenesis. D. A. Sampedro-Puente, J. Fernandez-Bes, N. Szentándrássy, P. Nánási, P. Taggart, E. Pueyo. Front Physiol, vol. 10, pp. 1547, 2020.

CONFERENCE PROCEEDINGS

- SK channel block and adrenergic stimulation counteract acetylcholine-induced arrhythmogenic effects in human atria. C. Celotto, C. Sánchez, K. Mountris, P. Laguna, E. Pueyo. Proc. 42nd Annual International Conference of the IEEE EMBS, pp. 2303-2306, 2020.

- Cardiac repolarization oscillations at sympathetic frequencies: characterization, underlying mechanisms and relation to arrhythmic risk. E. Pueyo. Proc. 11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO, 2020.

- Characterization of impaired repolarization by quantification of the QT delay in response to heart rate changes from stress test recordings. C. Pérez, E. Pueyo, J. P. Martínez, P. Laguna. Proc. 11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO, pp. 1-2, 2020.

- Sudden cardiac death prediction in chronic heart failure patients by periodic Repolarization Dynamics. S. Palacios, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Relationship between atrial oscillatory acetylcholine release pattern and f-wave frequency modulation: a computational and experimental study. C. Celotto, C. Sánchez, K. Mountris, M. Abdollahpur, F. Sandberg, P. Laguna, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Potassium monitoring from multilead T-wave morphology changes during hemodyalisis: Periodic versus Principal Component Analysis. F. Palmieri; P. Gomis; J.E. Ruiz; D. Ferreira; A. Martín-Yebra; E. Pueyo; P. Laguna; J.P. Martínez; J. Ramírez. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Next-generation in-silico cardiac electrophysiology through Immersed Grid Meshfree modeling. Application to simulation of myocardial infarction. K. Mountris, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- In silico characterization of repolarization duration and variability in the LQT1 syndrome under β-adrenergic stimulation. D.A. Sampedro-Puente, F. Raphel, J. Fernández-Bes, P. Laguna, D. Lombardi, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Improved methods for processing optical mapping signals from human left ventricular tissues at baseline and following adrenergic stimulation. M. Pérez-Zabalza, E.R. Diez, J. Rhyins, K. Mountris, J.M. Vallejo, P.C. Fresneda, J. Fañanás, M. Matamala, F. Sorribas, M. Vázquez, C. Ballester, M. Segovia-Roldán, A. Oliván-Viguera, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Changes in QRS and T-wave loops subsequent to an increase in left ventricle globularity as in intrauterine growth restriction: a simulation study. F.L. Bueno-Palomeque, K. Mountris, A. Mincholé, N. Ortigosa, R. Bailón, E. Pueyo, P. Laguna. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Analysis of nonlinear T wave dynamics by Lyapunov exponents for serum potassium monitoring in end-stage renal disease patients. S. Srinivasan, H.A. Bukhari, P. Laguna, C. Sánchez, E. Pueyo. Proc. XLVII International Conference on Computing in Cardiology, pp. 1-4, 2020.

- Retardo entre QT y RR en registros de prueba de esfuerzo como indicador de la heterogeneidad de la repolarización ventricular. C. Pérez-Martínez, E. Pueyo, J.P. Martínez, J. Viik, P. Laguna. Proc. XXXVIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 499 – 502, 2020.

- Predicción de muerte súbita en pacientes con insuficiencia cardíaca crónica mediante el estudio de la dinámica periódica de la repolarización. S. Palacios, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, E. Pueyo, P. Laguna, J.P. Martínez, J. Ramírez. Proc. XXXVIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 499 – 502, 2020.

- Monitorización en diálisis de la concentración de potasio en sangre mediante los cambios en la morfología multi-lead de la onda T: comparación entre usar la transformación en Componentes Periódicas y Principales. F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, P. Laguna, J.P. Martínez, J. Ramírez. Proc. XXXVIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 499 – 502, 2020.

- Caracterización in silico de la duración de la repolarización y su variabilidad en el síndrome de QT largo tipo1 bajo estimulación β adrenérgica. D.A. Sampedro-Puente, F. Raphel, J. Fernandez-Bes, P. Laguna, D. Lombardi, E. Pueyo. Proc. XXXVIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 499 – 502, 2020.

2019

JOURNAL PUBLICATIONS

- Cardiovascular risk predictive value and genetic contribution of the T-wave morphology restitution in the general population . J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, P. Lambiase, M. Orini, P. B. Munroe. Circ Arrhythm Electrophysiol, vol. 12, pp. e007549, 2019.

- Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. J. Lozano, A. Olivan-Viguera, P. Delgado, V. Singh, B.M. Brown, E. Tapia, E. Pueyo, M.S. Valero, A.L. Garcia, P. Giraldo, E. Abarca, J. Surra, J. Osada, K.L. Hamilton, M. Marigil, R.Khöler. Plos One, vol. 15, pp. e0222619, 2019.

- KCa3.1-transgene induction in murine intestinal epithelium causes duodenal chyme accumulation and impairs duodenal motility. M. S. Valero, M. Ramón-Giménez, J. Lozano-Gerona, P. Delgado-Wicke, P. Calmarza-Calmarza, A. Olivan-Viguera, V. López, A. L. García-Otín, S. Valero, E. Pueyo, K. L. Hamilton, H. Miura, R. Köhler. Int J Mol Sci, vol. 20, pp. 1193, 2019.

- Long-term microgravity exposure increases ECG repolarization instability manifested by low-frequency oscillations of T-wave vector. S. Palacios, E. G. Caiani, F. Landreani, J. P. Martínez, E. Pueyo. Front Physiol., vol. 10, pp. 1510, 2019.

- Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat variability of celullar ventricular repolarization in response to sympathetic stimulation: Implications for arrhythmogenesis. D. A. Sampedro, J. Fernández-Bes, B. Porter, S. van Duijvenboden, P. Taggart, E. Pueyo. Front Physiol., vol. 10, pp. 916, 2019.

CONFERENCE PROCEEDINGS

- Transcriptional analysis of human cardiac aging by chronological and biological age. L.García-Mendívil, E. Ramos-Marqués, J. C. Oliveros, R. Torres-Pérez, E. Pueyo, L. Ordovás. Proc. International Conference of Myocardial Function & Cellular Biology of the Heart, ESCARDIO, 2019.

- The role of microRNAs in age-related remodeling of the human left ventricle. E. Ramos, L. García-Mendívil, J.C. Oliveros, R. Torres, A. López, A. Olivan-Viguera, J.M. Vallejo, P.C. Fresneda, J. Fañanás, M. Matamala, F. Sorribas, M. Vázquez, C. Ballester, L. Ordovás, E. Pueyo. Proc. International Conference of Myocardial Function & Cellular Biology of the Heart, ESCARDIO, 2019.

- Histological characterization of age-related remodeling in human left ventricle by second harmonic generation and lipofuscin content. L. García-Mendívil, N. Smisdom; K. Mountris, A. Oliván, J.M. Vallejo, P.C. Fresneda, J. Fañanás, M. Matamala, F. Sorribas, M. Vázquez, C. Ballester, E. Wolfs, R.B. Driesen, L. Ordovás, E. Pueyo. Proc. International Conference of Myocardial Function & Cellular Biology of the Heart, ESCARDIO, 2019.

- Combined experimental and computational research into cardiac-neural interactions and arrhythmias. E. Pueyo. 41st Annual International Conference of the IEEE EMBS, In proc., 2019.

- The Genetic Architecture of T-wave Morphology Restitution. P. Lambiase, J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, M. Orini, P. Munroe. CompBioMed Conference, pp. 1-4, 2019.

- Transmural ventricular heterogeneities play a major role in determining T-wave morphology at different extracellular potassium levels. S. H. Ahmed, F. Palmieri, D. Ferreira, M. Potse, J. Ramírez, P. Laguna, C. Sánchez, E. Pueyo. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- T-wave morphology changes as surrogate for blood potassium concentration in hemodialysis patients. F. Palmieri, P. Gomis, J.E. Ruiz, B. Bergasa, A. Martín-Yebra, S. H. Ahmed, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- Small-conductance calcium-activated potassium current inhibition in autonomically stimulated human atrial myocytes: a computational investigation. C. Celotto, C. Sánchez, P. Laguna, E. Pueyo. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- Response of ventricular repolarization to simulated microgravity measured by Periodic Repolarization Dynamics using Phase-Rectified Signal Averaging. S. Palacios, E. G. Caiani, E. Pueyo, J. P. Martínez. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- Influence of the stimulation current on the differences between cell and tissue electrophysiological simulations. V. Monasterio, E. Pueyo, J. F. Rodríguez-Matas, J. Carro. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- A novel paradigm for in silico simulation of cardiac electrophysiology through the Mixed Collocation Meshless Petrov-Galerkin Method. K. Mountris, C. Sánchez, E. Pueyo. Proc. XLVI International Conference on Computing in Cardiology, pp. 1-4, 2019.

- A high-throughput system to reliably characterize normal human ventricular electrophysiology from living patients. A. Oliván-Viguera, J. Fernández-Bes, M.A. Marigil, J.M. Vallejo, C. Ballester, E. Pueyo. In Proc. European Working Group on Cardiac Cellular Electrophysiology, ESGCO, 2019.

2018

JOURNAL PUBLICATIONS

- A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes. J. Carro, E. Pueyo, J. F. Rodríguez . Plos One , vol. 13, pp. e0204411, 2018.

- On the standardization of approximate entropy: Multidimensional approximate entropy index evaluated on short-term HRV time series. J. Bolea, R. Bailón, E. Pueyo . Complexity, pp. 4953273, 2018.

- Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes . A. Oliván-Viguera, A. L. García-Otín, J. Lozano-Gerona, E. Abarca-Lachén, A. J. García-Malinis, K. L. Hamilton, Y. Gilaberte, E. Pueyo, R. Köhler . Plos One, vol. 13, pp. e0190307, 2018.

- Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond. E. Grandi, S. Morotti, E. Pueyo; B. Rodríguez. Front Physiol, vol. 9, pp. 678, 2018.

CONFERENCE PROCEEDINGS

- Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation. D.A. Sampedro, J. Fernández-Bes, B. Porter, S. Van Duijvenboden, P. Taggart, E. Pueyo. Proc. VPH, pp. 33, 2018.

- Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research. D.A. Sampedro, L. García-Mendívil, E. Ramos-Marqués, A. Oliván, J. Fernández-Bes, L. Ordovás, E. Pueyo. Proc. VPH, pp. 14, 2018.

- A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability. J. Fernández-Bes, D.A. Sampedro, E. Pueyo. Proc. VPH, pp. 19, 2018.

- Time course of cardiac electrical oscillatory behavior in response to enhanced sympathetic activity and relation to arrhytmogenesis. J. Fernández-Bes, D.A. Sampedro, P. Taggart, E. Pueyo. Proc. ESGCO – Biological Oscillations meeting, pp.1-4, 2018.

- Mechanisms underlying interactions between low-frequency oscillations and
beat-to-beat repolarization variability in human ventricles under sympathetic provocation
. D.A. Sampedro-Puente, J. Fernández-Bes, B. Porter, S. van Duijvenboden, P. Taggart, E. Pueyo. European Working Group on Cardiac Cellular Electrophysiology, In Proc., 2018.

- Transcriptional analysis of human cardiac aging by chronological and biological age. L. García-Mendívil; E. Ramos, J.C. Oliveros, R. Torres, J. Fernández-Bes, A. Oliván-Viguera, E. Pueyo, L. Ordovás. Cell Symposia Aging and Metabolism, In proc., 2018.

- Analysis of the role of microRNA in age-related heart electrophysiological remodeling. E. Ramos-Marqués, L. García-Mendívil, J.C. Oliveros, R. Torres-Pérez, A. Oliván-Viguera, L. Ordovás, E. Pueyo. Cell Symposia Aging and Metabolism, In proc., 2018.

- Noncoding RNAmediated metabolic regulation in health and disease. E. Ramos-Marqués, E. Pueyo. Current Trends in Biomedicine, In proc., 2018.

- La ingeniería como herramienta para combatir las enfermedades cardiovasculares. E. Pueyo. XXXVI Congreso Nacional de Ingeniería Hospitalaria, In proc., 2018.

- Characterization of abnormal cardiac dynamics in aged and failing hearts: insights from experimental and computational research. E. Pueyo. QBIO IV, In proc., 2018.

- Understanding heart function in health and disease with the help of mathematical models. E. Pueyo. II Joint Meeting Spain-Brazil in Mathematics, In proc., 2018.

- The morphology of the HR profile in an exercise stress test predicts cardiovascular mortality in the UK biobank cohort. J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini. Proc. XLV International Conference on Computing in Cardiology, vol. 44, pp. 785 – 788, 2018.

- Microgravity exposure alters sympathetic modulation of ventricular repolarization
quantified from the ECG via periodic repolarization dynamics
. S. Palacios, E.G. Caiani, J.P. Martínez, E. Pueyo. Proc. XLV International Conference on Computing in Cardiology, vol. 44, pp. 785 – 788, 2018.

- Inhomogeneous HRV spectral complexity: a preliminary evaluation with gravitational stimuli under selective autonomic blockade. J. Bolea, G. Valenza, R. Bailón, E. Pueyo, R. Barbieri. Proc. XLV International Conference on Computing in Cardiology, vol. 44, pp. 785 – 788, 2018.

- Influencia de la corriente de estimulación en las diferencias entre simulaciones electrofisiológicas de célula y tejido. V. Monasterio, J.F. Rodríguez-Matas, E. Pueyo, J. Carro. Proc. XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 125 – 128, 2018.

2017

JOURNAL PUBLICATIONS

- Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model. J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, P. Laguna, E. Pueyo. PLOS ONE, vol 12, pp. e0186152, 2017.

- Pulse rate and transit time analysis to predict hypotension events after spinal anesthesia during programmed cesarean labor. J. Bolea, J. Lázaro, E. Gil, E. Rovira, J. M. Remartínez, P. Laguna, E. Pueyo, A. Navarro, R. Bailón. Ann Biomed Eng, vol. 45, pp. 2253 – 2263, 2017.

- Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-waves. J. Ramírez, M. Orini, D. Tucker, E. Pueyo, P. Laguna. IEEE Trans Biomed Eng, vol. 64, pp. 1619–1630, 2017.

- T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure. J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, E. Pueyo, P. Laguna. J Am Heart Assoc, vol. 6, pp. e005310, 2017.

- Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics. C. Sánchez, A. Bueno-Orovio, E. Pueyo, B. Rodríguez. Front Bioeng Biotechnol, vol. 5, pp. 29, 2017.

- A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability. M. Orini, E. Pueyo, P. Laguna, R. Bailón. IEEE Trans Biomed Eng, vol 65, pp. 1443-1451, 2017.

- A methodology to improve human ventricular models for the investigation of cardiac arrhythmias. J. Carro, J. F. Rodríguez, E. Pueyo. Biophys J, vol. 112, pp. 403a, 2017. Published in abstract form.

CONFERENCE PROCEEDINGS

- Quantification of T-wave Morphological Variability Using Time-warping Methods. J. Ramírez, M. Orini, E. Pueyo, P. Laguna. Proc. EMBEC & NBC 2017, pp. 478-481, 2017.

- Multiscale methods for definition of ionic variables in electrophysiological models. J. Carro, J.F. Rodríguez, E. Pueyo. Proc. EMBEC & NBC 2017, pp. 115-118, 2017.

- In-silico investigation of ANS-Heart interactions: Implications for cardiac arrhythmias and therapeutic apporaches. E. Pueyo, M. Orini, J.F. Rodríguez, P. Taggart. In silico drug safety and efficacy Symposium, In proc., 2017.

- Identification of parameters describing phenomenological cardiac action potential models using sigma point methods. J. Fernandez-Bes, D.A. Sampedro-Puente, E. Pueyo. Proc. XLIV International Conference on Computing in Cardiology, pp. 197-200, 2017.

- Differential responses to beta-adrenergic stimulation in the long QT syndrome type 1: characterization and mechanisms. D.A. Sampedro-Puente, J. Fernandez-Bes, E. Pueyo. Proc. XLIV International Conference on Computing in Cardiology, pp. 882-885, 2017.

- Comparison of ECG Twave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure. J. Ramírez, M. Orini, E. Pueyo, P. Laguna. Proc. XLIV International Conference on Computing in Cardiology, pp. 785 – 788, 2017.

- T-Wave Morphology Restitution Dependency With Heart Rate Range And Its Association With Sudden Cardiac Death In Chronic Heart Failure. J. Ramírez, M. Orini, E. Pueyo, P. Laguna. Proc. XLIV International Conference on Computing in Cardiology, pp. 773 – 776, 2017.

- Caracterización de la respuesta a la estimulación betaadrenérgica en el síndrome LQT1. D.A. Sampedro, J. Fernández-Bes, E. Pueyo. Proc. XXXV Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 337 – 340, 2017.

- Unscented Kalman Filter para el ajuste de parámetros de modelos fenomenológicos de potencial de acción cardíaco. J. Fernández-Bes, D.A. Sampedro, E. Pueyo. Proc. XXXV Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp. 499 – 502, 2017.

2016

JOURNAL PUBLICATIONS

- Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans. E. Pueyo, M. Orini, J. F. Rodríguez, P. Taggart. J Mol Cell Cardiol, vol. 97, pp. 93-105, 2016.

- Ischemia detection from morphological QRS angle changes. D. Romero, J. P. Martínez, P. Laguna, E. Pueyo. Physiol Meas, vol. 37, pp. 1004, 2016.

- Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition. E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez. PLoS ONE, vol. 11, pp. e0151461, 2016.

- Influence of heart rate in nonlinear HRV indices as a sampling rate effect evaluated on supine and standing. J. Bolea, E. Pueyo, M. Orini, R. Bailón. Front Physiol, vol. 7, pp. 501, 2016.

- Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols. J. Carro, J. F. Rodríguez, V. Monasterio, E. Pueyo. Prog Biophys Mol Biol, DOI: 10.1016/j.pbiomolbio.2016.11.006, 2016.

- Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. J. Vicente, L. Johannesen, M. Hosseini, J. W. Mason, P. T. Sager, E. Pueyo, D. G. Strauss. PLoS ONE, vol. 11, pp. e0163619 , 2016.

- Techniques for ventricular repolarization instability assessment from the ECG. P. Laguna, J. P. Martínez, E. Pueyo. Proc IEEE, vol. 104, pp. 392-415, 2016.

CONFERENCE PROCEEDINGS

- An Index for T-wave Pointwise Amplitude Variability Quantification. J. Ramírez, M. Orini, J.D. Tucker, E. Pueyo, P. Laguna. Proc. XLIII International Conference on Computing in Cardiology, pp. 49-52, 2016.

2015

JOURNAL PUBLICATIONS

- High protein intake supplementation to compensate changes in ventricular repolarization due to 21-days of bedridden immobilization. EG. Caiani, A. Martín-Yebra, J. Bolea, A. Auricchio, E. Pueyo, P. Vaida. Eur Heart J, vol. 36, pp. 1145-1145, 2015.

- Erratum: QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death. J. Ramirez, P.Laguna, A. Bayés de Luna, M. Malik, E. Pueyo. J Electrocardiol, vol. 48(1), pp. 128-129, 2015.

- Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers. J. Ramírez, V. Monasterio, A. Mincholé, M. Llamedo, G. Lenis, I. Cygankiewicz, A. Bayés de Luna, M. Malik, J.P. Martínez, P. Laguna, E. Pueyo. J Electrocardiol, vol. 48, pp. 551-557, 2015.

- Comprehensive T Wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine and verapamil. J. Vicente, L. Johannesen, J.W. Mason, W.J. Crumb, E. Pueyo, N. Stockbridge, D.G. Strauss. J Am Heart Assoc, vol. 4, pp. e001615, 2015.

- ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. A. Mincholé, A. Bueno-Orovio, P. Laguna, E. Pueyo, and B. Rodríguez. J Electrocardiol, vol. 48, pp. 867-873, 2015.

- Sex Differences in Drug-Induced Changes in Ventricular Repolarization. J. Vicente, L. Johannesen, J. W. Mason, E. Pueyo, N. Stockbridge, D. G. Strauss. J Electrocardiol, vol. 58(6), pp.1081-1087, 2015.

CONFERENCE PROCEEDINGS

- The role of purkinje automaticity as an arrhythmia mechanism in hyperkalaemia. V. Monasterio, J. Carro, E. Pueyo, J.F. Rodríguez. Proc. XLII International Conference on Computing in Cardiology, pp. 873-876, 2015.

2014

JOURNAL PUBLICATIONS

- An electrocardiographic biomarker of ischemic preconditioning. L.P.B. Meijs, L. Galeotti, E. Pueyo, D. Romero, R.B. Jennings, M. Ringborn, S.G. Warren, G.S. Wagner, D.G. Strauss. Am J Physiol, vol. 307, pp. 80-87, 2014.

- Na/K pump regulation of cardiac repolarization: insights from a systems biology approach. A. Bueno-Orovio, C. Sánchez, E. Pueyo, B. Rodríguez. Pflugers Arch-Eur J Physiol, vol. 466, pp. 183–19, 2014.

- Modeling and quantification of repolarization feature dependency on heart rate. A. Mincholé, E. Zacur, E. Pueyo, P. Laguna. Methods Inf Med, vol. 53, pp. 324-328, 2014.

- Electrocardiogram derived respiratory rate from QRS slopes and R-wave angle. J. Lázaro, A. Alcaine, D. Romero, E. Gil, P. Laguna, E. Pueyo, R. Bailón. Ann Biomed Eng, vol. 40, pp. 2072-2083, 2014.

- Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation. C. Sánchez, A. Bueno-Orovio, E. Wettwer, S. Loose, U. Ravens, E. Pueyo, B. Rodríguez. PLOS ONE, vol 9, pp. e105897, 2014.

- QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: relation to sudden cardiac death. J. Ramírez, P. Laguna, A. Bayés de Luna, M. Malik, E. Pueyo. J Electrocardiol, vol. 47, pp. 842-848, 2014.

- T wave Morphology Assessment in a Randomized Double-blind Crossover Study of Four hERG Potassium Channel Blocking Drugs. J. Vicente, L. Johannesen, R.F. Afoakwa, E. Pueyo, N. Stockbridge, J. W. Mason, D. G. Strauss. Circulation, vol.130, pp. A14051, 2014. Published in abstract form.

CONFERENCE PROCEEDINGS

- Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework. G. Valenza, M. Orin. L. Citi, A. Minchole, E. Pueyo, P. Laguna, R. Barbieri. Proc. 8th Conference Of The European Study Group On Cardiovascular Oscillations, pp. 67-68, 2014.

- Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework. G. Valenza, M. Orin. L. Citi, A. Minchole, E. Pueyo, P. Laguna, R. Barbieri. Proc. 8th Conference Of The European Study Group On Cardiovascular Oscillations, pp. 67-68, 2014.

- Non-linear HRV indices under autonomic nervous system blockade. J. Bolea, E. Pueyo, P. Laguna and R. Bailón. Proc. 36nd Annual International Conference of the IEEE EMBS, pp. 3252-3255, 2014.

- Assessing Real-Time RR-QT Frequency-Domain Measures of Coupling and Causality through Inhomogeneous Point-Process Bivariate Models. G. Valenza, M. Orin. L. Citi, A. Minchole, E. Pueyo, P. Laguna, R. Barbieri. Proc. 36nd Annual International Conference of the IEEE EMBS, pp. 6475-6478, 2014.

- In Silico Simulations of Experimental Protocols for Cardiac Modeling. J. Carro, J. F. Rodríguez, E. Pueyo. Proc. 36nd Annual International Conference of the IEEE EMBS, pp. 5695-5698, 2014.

- Analysis of QRS Alterations during Stress Test Recordings on Patients with Brugada Syndrome. D. Romero, N. Behar, A. Martín-Yebra, J. P. Martínez, P. Laguna, E. Pueyo, G. Carrault, P. Mabo, A. Hernández. Proc. XLI International Conference on Computing in Cardiology, pp. 137-140, 2014.

- Circadian Pattern and Sex Differences of QT/RR and T-peak-to-end/RR Curvatures and Slopes in Chronic Heart Failure Patients. J. Ramírez, I. Cygankiewicz, P. Laguna, M. Malik, E. Pueyo. Proc. XLI International Conference on Computing in Cardiology, pp. 173-176, 2014.

- Detection of Acute Ischemia Episodes from QRS Angles Changes using a Laplacian Noise Model. D. Romero, J. P. Martínez, P. Laguna, E. Pueyo. Proc. XLI International Conference on Computing in Cardiology, pp. 629-632, 2014.

- Repolarization alternans in human ventricular hyperkalaemic tissue: dependence on current stimulation. V. Monasterio, J. Carro, E. Pueyo. Proc. XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp.1-4, 2014.

- Modulación Circadiana y de Género de las Relaciones QT/RR y T-pico-a-fin/RR en Pacientes con Insuficiencia Cardiaca. J. Ramírez, P. Laguna, E. Pueyo. Proc. XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, pp.1-4, 2014.

2013

JOURNAL PUBLICATIONS

- Signal processing guided by physiology: making the most of biomedical signals. E. Pueyo, R. Bailón, E. Gil, J.P. Martínez, P. Laguna. IEEE Signal Proc Mag, vol. 30, pp. 136–142, 2013.

- Detecting acute myocardial ischemia by evaluation of QRS angles. D. Romero, P. Laguna, E. Pueyo. Int J Bioelectromagn, vol. 15, pp. 77–82, 2013.

- Detection and quantification of acute myocardial ischemia by morphologic evaluation of QRS changes by an angle-based method. D. Romero, M. Ringborn, P. Laguna, E. Pueyo. J Electrocardiol, vol. 46, pp. 204–214, 2013.

- Coronary Artery Disease diagnosis by analysis of ECG depolarization. E. Pueyo. J Electrocardiol, vol. 46, pp. 27–28, 2013.

CONFERENCE PROCEEDINGS

- Very low frequency modulation in QRS slopes and its relation with respiration and heart rate variability during hemodialysis. D. Hernando, A. Alcaine, P. Laguna, E. Pueyo, R. Bailón. Proc. 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 5365–5368, 2013.

- Cell Repolarization Variability Modulates Atrial FibrillationDynamics in 3D Virtual Human Atria. C. Sanchez, A. Bueno-Orovio, E. Pueyo, B. Rodríguez. Proc. XL International Conference on Computing in Cardiology, pp. 911-914, 2013.

- Repolarization Variability Mechanisms and its Relation with Cardiac Arrhytmogenesis. J. F. Rodríguez, R. Sassi, E. Pueyo, L. Mainardi. Proc. XL International Conference on Computing in Cardiology, pp. 341-344, 2013.

- Influence of Respiration in the Very Low Frequency Modulation of QRS slopes and Heart Rate Variability in Cardiomyopathy Patients. D. Hernando, A. Alcaine, E. Pueyo, P. Laguna, M. Orini, A. Arcentales, B. Giraldo, A. Voss, A. Bayés-Genís, R. Bailón. Proc. XL International Conference on Computing in Cardiology, pp. 117-120, 2013.

- Prediction of Sudden Cardiac Death in Chronic Heart Failure Patients by Analysis of Restitution Dispersion. J. Ramírez, A. Mincholé, J. Bolea, P. Laguna, E. Pueyo. Proc. XL International Conference on Computing in Cardiology, pp. 1-4, 2013.

- Morphologic Features of the ECG for Detection of Stress-Induced Ischemia. M. Llamedo, J. P. Martínez, M. Albertal, D. Romero, E. Pueyo, P. Laguna. Proc. XL International Conference on Computing in Cardiology, pp. 591-594, 2013.

2012

JOURNAL PUBLICATIONS

- Characterization of ventricular depolarization changes in a porcine model of myocardial infarction. D. Romero, M. Ringborn, M. Demidova, S. Koul, P. Laguna, P. Platonov, E. Pueyo. Physiol Meas, vol. 33, pp. 1975–1991, 2012.

- The Na+/ K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue. C. Sánchez, A. Corrias, M. Davies, J. Swinton, I. Jacobson, P. Laguna, E. Pueyo, B. Rodríguez. Am J Physiol, vol. 302, pp. 1146–1159, 2012.

- Impact of Multiple Ionic Changes in Arrhythmic Risk Biomarkers in Human Ventricular Electrophysiology. J.F. Rodríguez, J. Carro, E. Pueyo, K. Burrage, B. Rodríguez. Biophys J, vol. 102(3), pp. 543– 543, 2012. Published in abstract form.

CONFERENCE PROCEEDINGS

- Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model. C. Sánchez, M. Krueger, G. Seeman, O. Dössel, E. Pueyo, B. Rodríguez. Proc. Computing in Cardiology, vol. 38, pp. 137– 140, 2012.

- Characterization of cardiac repolarization response to heart rate changes provoked by a tilt test. J. Ramírez, A. Mincholé, P. Laguna, E. Pueyo. Proc. Computing in Cardiology, vol. 38, pp. 673–676, 2012.

- Microgravity effects on ventricular response to heart rate changes. J. Bolea, E.G. Caiani, E. Pueyo, P. Laguna, R. Almeida. Proc. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 12), Proc. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 12), 2012.

- A novel ECG-based biomarker quantifying APD restitution dispersion improves risk stratification following sotalol administration. A. Mincholé, A. Bueno-Orovio, P. Laguna, E. Pueyo, B. Rodríguez. Proc. VII International Workshop on Biosignal Interpretation, pp. 105–108, 2012.

- Robust characterization of repolarization adaptation to heart rate changes. A. Mincholé, E. Zacur, E. Pueyo, P. Laguna. Proc. VII International Workshop on Biosignal Interpretation, pp. 287–290, 2012.

- Detecting acute myocardial ischemia by evaluation of QRS angles. D. Romero, P. Laguna, E. Pueyo. Proc. VII International Workshop on Biosignal Interpretation, pp. 65–68, 2012.

2011

JOURNAL PUBLICATIONS

- A multi-scale investigation of repolarization variability and its role in cardiac arrhythmogenesis. E. Pueyo, A. Corrias, L. Virág, N. Jost, T. Szel, A. Varró, N. Szentandrássy, P. Nánási, K. Burrage, B. Rodríguez. Biophys J, vol. 101, pp. 2892–2902, 2011.

- A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalemic conditions. J. Carro, J.F. Rodríguez, P. Laguna, E. Pueyo. Philos Trans R Soc Lond A, vol. 369, pp. 4205– 4232, 2011.

- Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes. M. Ringborn, D. Romero, E. Pueyo, O. Pahlm, G. Wagner, P. Laguna, P. Platonov. J Electrocardiol, vol. 44, pp. 416–424, 2011.

- Quantification of restitution dispersion from the dynamic changes of the T wave peak to end, measured at the surface ECG. A. Mincholé, E. Pueyo, J.F. Rodríguez, E. Zacur, P. Laguna. IEEE Trans Biomed Eng, vol. 58, pp. 1172–1182, 2011.

- Depolarization changes during acute myocardial ischemia by evaluation of QRS slopes. Standard lead and vectorial approach. D. Romero, M. Ringborn, P. Laguna, O. Pahlm, E. Pueyo. IEEE Trans Biomed Eng, vol. 58, pp. 110–120, 2011.

CONFERENCE PROCEEDINGS

- Influence of simulated microgravity by head-down-bed-resting on QT/RR dynamics. J. Bolea, E. Pueyo, R. Almeida, M. Llamedo, M. Sotaquirá, J.P. Martínez, P. Laguna, E.G. Caiani. Proc. Computing in Cardiology, vol. 37, pp. 441–444, 2011.

- ECG amplitude modulation in the very-lowfrequency band in patients with angina pectoris. A. Alcaine, R. Bailón, D. Romero, E. Pueyo, P. Laguna. Proc. Computing in Cardiology, vol. 37, pp. 757– 760, 2011.

2010

JOURNAL PUBLICATIONS

- High-throughput cardiac science on the grid. D. Abramson, M. Bernabeu, B. Bethwaite, K. Burrage, A. Corrias, C. Enticott, S. Garic, D. Gavaghan, T. Peachey, J. Pitt-Francis, E. Pueyo, B. Rodríguez, A. Sher, K. Tan. Philos Trans R Soc Lond A, vol. 368, pp. 3907–3923, 2010.

- Arrhythmic Risk Biomarkers for the Assessment of Drug Cardiotoxicity: from experiments to computer simulations. A. Corrias, X. Jie, L. Romero, M.J. Bishop, M.O. Bernabeu, E. Pueyo, B. Rodríguez. Philos Trans R Soc Lond A, vol. 368, pp. 3001–3025, 2010.

- Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk. E. Pueyo, Z. Husti, T. Hornyik, I. Baczkó, P. Laguna, A. Varró, B. Rodríguez. Am J Physiol, vol. 298, pp. 1577–1587, 2010.

- Dispersion of APD restitution quantified from the surface ECG. A. Mincholé, E. Pueyo, P. Laguna. Electrocardiol, vol. 43, pp. 643–644, 2010. Published in abstract form.

CONFERENCE PROCEEDINGS

- Analysis and improvement of a human ventricular cell model for investigation of cardiac arrhythmias. J. Carro, J.F. Rodríguez, P. Laguna, E. Pueyo. Proc. Computing in Cardiology, vol. 36, pp. 817–820, 2010.

- Torsadogenic drug-induced increased short-term variability of JTarea. X. Jie, B. Rodríguez, E. Pueyo. Proc. Computing in Cardiology, vol. 36, pp. 353–356, 2010.

- A vectorial approach for evaluation of depolarization changes during myocardial ischemia. D. Romero, M. Ringborn, P. Laguna, O. Pahlm, E. Pueyo. Proc. Computing in Cardiology, vol. 36, pp. 265–268, 2010.

- Potential pharmacological therapies for atrial fibrillation. A computational study. C. Sánchez, A. Corrias, P. Laguna, M. Davies, J. Swinton, I. Jacoboson, E. Pueyo, B. Rodríguez. Proc. Computing in Cardiology, vol. 36, pp. 413–416, 2010.

- Evaluation of a method for quantification of restitution dispersion from the surface ECG. A. Mincholé, E. Pueyo, J.F. Rodríguez, E. Zacur, M. Doblaré, P. Laguna. Proc. Computing in Cardiology, vol. 36, pp. 773–776, 2010.

- A new ECG biomarker for drug toxicity: a combined signal processing and computational modeling study. X. Jie, B. Rodríguez, E. Pueyo. Proc. 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 10), pp. 2565–2568, 2010.

2009

JOURNAL PUBLICATIONS

- Impact of ionic current variability on human ventricular cellular electrophysiology. L. Romero, E. Pueyo, M. Fink, B. Rodríguez. Am J Physiol, vol. 297(4), pp. 1436–1445, 2009.

- Cardiac repolarisation analysis using the surface ECG. E. Pueyo, J.P. Martínez, P. Laguna. Philos Trans R Soc Lond A, vol. 367, pp. 313–323, 2009.

CONFERENCE PROCEEDINGS

- Transmural Differences in Rate Adaptation of Repolarization Duration Quantified from ECG Repolarization Interval Dynamics. A. Minchole, E. Pueyo, P. Laguna. Proc. Computers in Cardiology, vol. 35, pp. 597–600, 2009.

- Spatial Characterization of Ischemia in 12-lead ECG Recordings during PCI using both Depolarization and Repolarization Indices. D. Romero, E. Pueyo, M. Ringborn, P. Laguna. Proc. Computers in Cardiology, vol. 35, pp. 113–116, 2009.

- Cardiac Memory in Human Atria and Relation to Arrhythmogenesis. C. Sánchez, E. Pueyo, P. Laguna, B. Rodríguez. Proc. Computers in Cardiology, vol. 35, pp. 113–116, 2009.

2008

JOURNAL PUBLICATIONS

- QRS slopes for detection and characterization of myocardial ischemia. E. Pueyo, L. Sörnmo, P. Laguna. IEEE Trans Biomed Eng, vol. 55(2), pp. 468–477, 2008.

- A dynamic model to characterize beat-to-beat adaptation of repolarization to heart rate changes. E. Pueyo, M. Malik, P. Laguna. Biomed Signal Process Control, vol. 3, pp. 29–43, 2008.

2007

JOURNAL PUBLICATIONS

- Evaluation of QRS Slopes for Determination of Myocardial Damage in Chronic Chagasic Patients. E. Pueyo, E. Laciar, E. Anzuola, P. Laguna, R. Jané. Journal of Physics Conference Series, vol. 90, num. 012077, 2007.

CONFERENCE PROCEEDINGS

- Dynamic Repolarization Assessment and Arrhythmic Risk Stratification. E. Pueyo, M. Malik, P. Laguna. Proc. 11th Mediterranean Conference on Medical and Biological Engineering and Computing, vol. 16, 2007.

- Study of the Dynamic Relationship between T Wave Morphology Changes and Heart Rate during Ischemia. F. Simón, P. Laguna, E. Pueyo. Proc. Computers in Cardiology, vol. 34, pp. 297–300, 2007.

- Assessment of Myocardial Damage in Chronic Chagasic Patients using QRS Slopes. E. Pueyo, E. Laciar, E. Anzuola, P. Laguna, R. Jané. Proc. Computers in Cardiology, vol. 34, pp. 725–728, 2007.

2006

JOURNAL PUBLICATIONS

- QT variability and HRV interactions in ECG: quantification and reliability. R. Almeida, S. Gouveia, A.P. Rocha, E. Pueyo, J.P. Martínez, P. Laguna. IEEE Trans Biomed Eng, vol. 53(7), pp. 1317–1329, 2006.

2005

CONFERENCE PROCEEDINGS

- Beat-to-beat adaptation of QT interval to heart rate. E. Pueyo, M. Malik, P. Laguna. Proc. 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 05), pp. 769–772, 2005.

- High-frequency signature of the QRS complex across ischemia quantified by QRS slopes. E. Pueyo, A. Arciniega, P. Laguna. Proc. Computers in Cardiology, vol. 32, pp. 659–662, 2005.

2004

JOURNAL PUBLICATIONS

- Time course of ECG depolarization and repolarization changes during ischemia in PTCA recordings. E. Pueyo, J. García, G.Wagner, R. Bailón, L. Sörnmo, P. Laguna. Methods Inf Med, vol. 43(1), pp. 43– 46, 2004.

- Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone. P. Smetana, E. Pueyo, K. Hnatkova, V. Batchvarov, P. Laguna, M. Malik. J Cardiovasc Electrophysiol, vol. 15(10), pp. 1147–1154, 2004.

- Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction. E. Pueyo, P. Smetana, P. Caminal, A. Bayés de Luna, M. Malik, P. Laguna. IEEE Trans Biomed Eng, vol. 51(9), pp. 1511–1520, 2004.

- Assessment of the individual QT/RR relationship and hysteresis in post-infarction patients. E. Pueyo, P. Smetana, P. Laguna, M. Malik. Ital Heart J, vol. 5(1), pp. 165–168, 2004.

- Speed of QT rate adaptation predicts risk in myocardial infarction survivors. P. Smetana, E. Pueyo, H. Hnatkova, V. Batchvarov, M. Malik. J Am Coll Cardiol, vol. 43(5), pp. 108–109, 2004. Published in abstract form.

- Both beta-blockers and amiodarone increase speed of QT/heart rate adaptation. P. Smetana, E. Pueyo, H. Hnatkova, V. Batchvarov, M. Malik. J Am Coll Cardiol, vol. 43(5), pp. 494–494, 2004. Published in abstract form.

CONFERENCE PROCEEDINGS

- Quantification of the QT variability related to HRV: robustness study facing automatic delineation and noise on the ECG. R. Almeida, E. Pueyo, J. P. Martínez, A. P. Rocha, P. Laguna. Proc. Computers in Cardiology, vol. 31, pp. 769–772, 2004.

2003

JOURNAL PUBLICATIONS

- Effect of amiodarone on the descending limb of the T wave. P. Smetana, E. Pueyo, K. Hnatkova, V. Batchvarov, A. J. Camm, M. Malik. Am J Cardiol, vol. 92(6), pp. 742–746, 2003.

- Estimation of the QT/RR hysteresis lag. E. Pueyo, P. Smetana, P. Laguna, M. Malik. J Electrocardiol, vol. 36, pp. 187–190, 2003.

- Antiarrhythmic efficacy of amiodarone is predicted by changes in the QT/RR relationship. P. Smetana, E. Pueyo, H. Hnatkova, V. Batchvarov, A. J. Camm, M. Malik. Eur Heart J, vol. 24, pp. 720–720, 2003. Published in abstract form.

- Lack of QT prolongation with amiodarone increases arrhythmic risk. P. Smetana, E. Pueyo, H. Hnatkova, M. Malik. J Am Coll Cardiol, vol. 41(6), pp. 103–103, 2003. Published in abstract form.

- Amiodarone increases transmural heterogeneity of repolarization in patients with cardiac death. P. Smetana, E. Pueyo, H. Hnatkova, M. Malik. J Am Coll Cardiol, vol. 41(6), pp. 109–110, 2003. Published in abstract form.

CONFERENCE PROCEEDINGS

- A parametric model approach for quantification of short term QT variability uncorrelated with heart rate variability. R. Almeida, E. Pueyo, J. P. Martínez, A. P. Rocha, S. Olmos, P. Laguna. Proc. Computers in Cardiology, vol. 30, pp. 165–168, 2003.

- Evaluation of QT interval response to marked RR interval changes selected automatically in ambulatory recordings. E. Pueyo, P. Smetana, M. Malik, P. Laguna. Proc. Computers in Cardiology, vol. 30, pp. 157–160, 2003.

2002

JOURNAL PUBLICATIONS

- Modification of QT/RR adaptation by amiodarone is related to reduction in arrhythmic mortality in post-myocardial infarction patients. E. Pueyo, V. Batchvarov, P. Smetana, M. Malik. Circulation, vol. 106(19), pp. 373–374, 2002. Published in abstract form.

CONFERENCE PROCEEDINGS

- Time for QT adaptation to RR Changes and relation to arrhythmic mortality reduction in amiodarone-treated patients. E. Pueyo, P. Smetana, K. Hnatkova, P. Laguna, M. Malik. Proc. Computers in Cardiology, vol. 29, pp. 565–568, 2002.

- Time course of ECG depolarization and repolarization changes during ischemia in PTCA recordings. E. Pueyo, J. García, G.Wagner, R. Bailón, L. Sörnmo, P. Laguna. Proc. IV International Workshop on Biosignal Interpretation, pp. 115–118, 2002.